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The concomitant utilization of opioids with other opioid analgesics, for example butorphanol, nalbuphine, pentazocine, may well lessen the analgesic impact of acetaminophen and codeine phosphate tablets and/or precipitate withdrawal signs.

If concomitant usage of a CYP3A4 inhibitor is necessary or if a CYP3A4 inducer is discontinued, look at dosage reduction of acetaminophen and codeine phosphate tablets until finally secure drug results are obtained. Appraise individuals at Recurrent intervals for respiratory depression and sedation.

-Doses greater than 60 mg have not been proven to improve ache reduction and therefore are affiliated with a heightened incidence of adverse consequences.

Acetaminophen and codeine phosphate tablets are contraindicated for postoperative administration in pediatric clients younger than 18 decades of age next tonsillectomy and/or adenoidectomy (see CONTRAINDICATIONS).

When discontinuing or decreasing opioid doses in sufferers who have already been acquiring therapy for an prolonged time period and/or at better doses for Serious pain, a multimodal method of pain management may possibly improve the remedy of Long-term suffering, as well as help with the successful tapering from the opioid analgesic.

You'll have some acetaminophen and codeine phosphate tablets remaining above you didn't use. See disposal data at the bottom of this area for directions regarding how to safely and securely throw away (get rid of) your unused acetaminophen and codeine phosphate tablets.

Assess Every single affected person's possibility previous to prescribing and observe all patients routinely for the development of those behaviors or problems.

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Accidental Ingestion Accidental ingestion of even one dose of acetaminophen and codeine phosphate tablets, Particularly by kids, can lead to a fatal more info overdose of acetaminophen and codeine (see WARNINGS).

Acetaminophen and codeine phosphate tablets are contraindicated for postoperative administration in pediatric sufferers more youthful than eighteen yrs of age adhering to tonsillectomy and/or adenoidectomy (see CONTRAINDICATIONS).

Screen people for possibility of material use Diseases, which include opioid abuse and get more info misuse, and warn them of the risk for overdose read more and Dying linked to the use of additional CNS get more info depressants which include alcohol and illicit prescription drugs check here (see Safeguards, Drug Interactions and Information for People/Caregivers).

Use with warning; start with decrease doses or with for a longer period dosing intervals and titrate gradually even though meticulously checking for Unwanted side effects.

Assess people getting acetaminophen and codeine phosphate tablets and any CYP3A4 inhibitor or inducer for symptoms and signs and symptoms that may mirror opioid toxicity and opioid withdrawal when acetaminophen and codeine phosphate tablets are used along with inhibitors and inducers of CYP3A4 (see Safety measures, Drug Interactions).

Neonatal Opioid Withdrawal Syndrome: Prolonged use for the duration of pregnancy may end up in neonatal opioid withdrawal syndrome, which can be everyday living-threatening Otherwise recognized and handled, and calls for administration In keeping with protocols developed by neonatology specialists.